Sodium butyrate
SIAL/B5887 - ≥98.5% (GC)
Synonym: Butyric acid sodium salt
CAS Number: 156-54-7
Empirical Formula (Hill Notation): C4H7NaO2
Molecular Weight: 110.09
EC Number: 205-857-6
MDL Number: MFCD00002816
Linear Formula: CH3CH2CH2COONa
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B5887-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B5887-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B5887-5G
| assay | ≥98.5% (GC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C4H8O2.Na/c1-2-3-4(5)6 |
| InChI key | MFBOGIVSZKQAPD-UHFFFAOYSA |
| mp | 250-253 °C (lit.) |
| Quality Level | 200  |
| SMILES string | [Na+].CCCC([O-])=O |
| solubility | water: 100 mg/mL, clear to slightly hazy, colorless |
| storage temp. | room temp |
| Application: | Sodium butyrate has been used: • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells. • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay. • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor. |
| Biochem/physiol Actions: | Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis. |
| Caution: | Hygroscopic |
| Packaging: | 1, 5 g in glass bottle |
| Packaging: | 250 mg in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 - H314 |
| Precautionary statements | P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-68 |
| Safety Statements | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.5% (GC) |
| mp | 250-253 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |