Benzamidine hydrochloride hydrate
SIAL/B6506 - ≥99%
Synonym: Amidinobenzene hydrochloride; Benzamidinium chloride; Benzenecarboximidamide hydrochloride
CAS Number: 206752-36-5
Empirical Formula (Hill Notation): C7H8N2 · ClH · xH2O
Molecular Weight: 156.61 (anhydrous basis)
EC Number: 216-795-4
MDL Number: MFCD00066285
Linear Formula: C6H5C(=NH)NH2 · HCl · xH2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6506-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6506-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6506-5G
| assay | ≥99% |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C7H8N2.ClH.H2O/c8-7(9) |
| InChI key | BQVJCMMLDJPBFZ-UHFFFAOYSA |
| mp | 86-88 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Cl[H].[H]O[H].NC(=N)c1ccc |
| solubility | water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow |
| storage temp. | 2-8°C |
| Application: | Benzamidine hydrochloride hydrate has been used: • in western blot analysis • in immunoprecipitation • in the purification of yeast dynein • as a protease inhibitor in the preparation of brush-border membrane vesicles • for the processing of human synovial fluid, blood and eye sleep • to prevent non-specific degradation of cartilages |
| Biochem/physiol Actions: | Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A. In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma. |
| Biochem/physiol Actions: | Peptidase inhibitor. |
| Packaging: | 5, 25, 100 g in glass bottle |
| Preparation Note: | Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 86-88 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |