Miconazole nitrate

SIAL/BP253 - British Pharmacopoeia (BP) Reference Standard

Synonym: (±)-Miconazole nitrate salt; 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

CAS Number: 22832-87-7
Empirical Formula (Hill Notation): C₁₈H₁₄Cl₄N₂O · HNO₃
Molecular Weight: 479.14
EC Number: 245-256-6
MDL Number: MFCD00058161
Linear Formula: C₁₈H₁₄Cl₄N₂O · HNO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-BP253	100 mg	$223.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	miconazole
application(s)	pharmaceutical pharmaceutical small molecule
form	solid
format	neat
grade	pharmaceutical primary standard
InChI	1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChI key	MCCACAIVAXEFAL-UHFFFAOYSA-N
manufacturer/tradename	BP
shelf life	limited shelf life, expiry date on the label
SMILES string	ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
storage temp.	2-8°C

Application:	Miconazole nitrate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia. Also used in monographs such as: Miconazole and Hydrocortisone Acetate Cream • Miconazole and Hydrocortisone Cream • Miconazole and Hydrocortisone Ointment • Miconazole Eye Drops • Miconazole Oromucosal Gel • Miconazole Cream
Biochem/physiol Actions:	Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes:	Sales restrictions may apply.
Packaging:	Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H317
Precautionary statements	P280 - P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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