Proguanil hydrochloride
SIAL/BP297 - British Pharmacopoeia (BP) Reference Standard
Synonym: Chlorguanide; N1-(4-Chlorophenyl)-N5-isopropylbiguanide
CAS Number: 637-32-1
Empirical Formula (Hill Notation): C11H16ClN5·HCl
Molecular Weight: 290.19
EC Number: 211-283-7
MDL Number: MFCD01732193
Linear Formula: C11H16ClN5·HCl
Product Type: Chemical
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C11H16ClN5.ClH/c1-7(2) |
InChI key | SARMGXPVOFNNNG-UHFFFAOYSA |
manufacturer/tradename | BP |
SMILES string | Cl.CC(C)NC(=N)NC(=N)Nc1cc |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains. |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. |
Other Notes: | Sales restrictions may apply. |
Packaging: | Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia ![]() ![]() |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P330 + P331 + P310 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |