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Proguanil hydrochloride

SIAL/BP297 - British Pharmacopoeia (BP) Reference Standard

Synonym: Chlorguanide; N1-(4-Chlorophenyl)-N5-isopropylbiguanide

CAS Number: 637-32-1
Empirical Formula (Hill Notation): C11H16ClN5·HCl
Molecular Weight: 290.19
EC Number: 211-283-7
MDL Number: MFCD01732193
Linear Formula: C11H16ClN5·HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-BP297 100 mg
 $223.00
1/EA		 Add To Favorites

 

API family proguanil
application(s) pharmaceutical
pharmaceutical small molecule
form solid
format neat
grade pharmaceutical primary standard
InChI 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
InChI key SARMGXPVOFNNNG-UHFFFAOYSA-N
manufacturer/tradename BP
shelf life limited shelf life, expiry date on the label
SMILES string Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
storage temp. 2-8°C
Application: Proguanil hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Proguanil Tablets
    		•
    Biochem/physiol Actions: Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
    General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
    Other Notes: Sales restrictions may apply.
    Packaging: Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 
    Symbol GHS06  GHS06
    Signal word Danger
    Hazard statements H301
    Precautionary statements P301 + P330 + P331 + P310
    RIDADR UN 2811 6.1 / PGIII
    WGK Germany WGK 3
    Flash Point(F) Not applicable
    Flash Point(C) Not applicable
    Storage Temp. 2-8°C
    UNSPSC 12352200

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