Tetracycline hydrochloride

SIAL/BP480 - British Pharmacopoeia (BP) Reference Standard

CAS Number: 64-75-5
Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₈ · HCl
Molecular Weight: 480.90
EC Number: 200-593-8
MDL Number: MFCD00078142
Linear Formula: C₂₂H₂₄N₂O₈ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-BP480	100 mg	$211.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	tetracycline
application(s)	pharmaceutical pharmaceutical small molecule
form	crystalline powder
format	neat
grade	pharmaceutical primary standard
InChI	1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChI key	XMEVHPAGJVLHIG-FMZCEJRJSA-N
manufacturer/tradename	BP
mp	220-223 °C (lit.)
shelf life	limited shelf life, expiry date on the label
SMILES string	Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
storage temp.	−20°C

Application:	Tetracycline hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia. Also used in monographs such as: Lymecycline Capsules • Chlortetracycline Eye Ointment • Chlortetracycline Veterinary Oral Powder • Chlortetracycline Tablets • Chlortetracycline Ointment • Doxycycline Tablets • Doxycycline Prolonged-Release Capsules • Doxycycline Dispersible Tablets • Doxycycline Capsules • Tetracycline Tablets • Tetracycline Capsules
Biochem/physiol Actions:	Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action. Mode of Resistance: The effects are inactivated via a loss of cell wall permeability. Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes:	Sales restrictions may apply.
Packaging:	Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Symbol	GHS08,GHS09
Signal word	Warning
Hazard statements	H361d - H411
Precautionary statements	P201 - P273 - P308 + P313
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2

mp	220-223 °C (lit.)
Storage Temp.	−20°C
UNSPSC	12352200

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