Simvastatin

SIAL/BP739 - British Pharmacopoeia (BP) Reference Standard

CAS Number: 79902-63-9
Empirical Formula (Hill Notation): C₂₅H₃₈O₅
Molecular Weight: 418.57
MDL Number: MFCD00072007
Linear Formula: C₂₅H₃₈O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-BP739	100 mg	$227.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	simvastatin
application(s)	pharmaceutical pharmaceutical small molecule
form	powder
format	neat
grade	pharmaceutical primary standard
InChI	1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChI key	RYMZZMVNJRMUDD-HGQWONQESA-N
manufacturer/tradename	BP
mp	127-132 °C (lit.)
shelf life	limited shelf life, expiry date on the label
SMILES string	[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)C(C)(C)CC
storage temp.	−20°C

Application:	Simvastatin BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia. Also used in monographs such as: Simvastatin Tablets • Simvastatin Oral Suspension
Biochem/physiol Actions:	Simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. It is used in the treatment of hypercholesterolemia, as it reduces levels of low-density lipoproteins and triglycerides, and raises high-density lipoprotein levels. Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding β-hydroxyacid, and can be activated prior to use with NaOH in EtOH treatment. It is a synthetic analog of lovastatin (Cat. No. M2147).
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes:	Sales restrictions may apply.
Packaging:	Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Symbol	GHS08
Signal word	Warning
Hazard statements	H361d
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	127-132 °C (lit.)
Storage Temp.	−20°C
UNSPSC	12352200

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