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Calcitriol

SIAL/C0225000 - European Pharmacopoeia (EP) Reference Standard

Synonym: 1α,25-Dihydroxyvitamin D3; 1α,25-Dihydroxycholecalciferol; Calcitriol

CAS Number: 32222-06-3
Empirical Formula (Hill Notation): C27H44O3
Molecular Weight: 416.64
MDL Number: MFCD00867079
Linear Formula: C27H44O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C0225000 10 mg
 $1930.00
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agency EP
API family calcitriol
application(s) pharmaceutical (small molecule)
biological source sheep wool (grease)
form solid
format neat
grade pharmaceutical primary standard
InChI 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key GMRQFYUYWCNGIN-NKMMMXOESA-N
manufacturer/tradename EDQM
SMILES string [H][C@@]1(CC[C@@]2([H])C(CCC[C@]12C)=CC=C3C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
storage temp. −20°C
technique(s) gas chromatography (GC): suitable
  liquid chromatography (LC): suitable
Application: Calcitriol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions: Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia .

Calcitriol is a biologically active metabolite of vitamin D, formed via hydroxylation of calcidiol in the kidney.
Other Notes: Sales restrictions may apply.
Packaging: The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .
Storage Temp. −20°C
UNSPSC 41116107

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