Synonym: Folinic acid calcium salt hydrate; 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt; 5-HCO-H4PteGlu; Calcium folinate; Citrovorum factor calcium salt; Leucovorin calcium salt
CAS Number: 1492-18-8 (anhydrous)
Empirical Formula (Hill Notation): C20H21CaN7O7 · xH2O
Molecular Weight: 511.50 (anhydrous basis)
Linear Formula: C20H21CaN7O7 · xH2O
Product Type: Chemical
| agency |
EP |
| API family |
folic acid |
| application(s) |
pharmaceutical (small molecule) |
| biological source |
synthetic |
| form |
solid |
| format |
neat |
| grade |
pharmaceutical primary standard |
| InChI |
1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1 |
| InChI key |
KVUAALJSMIVURS-ZEDZUCNESA-L |
| manufacturer/tradename |
EDQM |
| SMILES string |
[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13 |
| storage temp. |
2-8°C |
| technique(s) |
gas chromatography (GC): suitable |
| |
liquid chromatography (LC): suitable |
| Application: |
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
| General description: |
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . Calcium folinate (CF) is a folic acid derivative. It is a naturally occurring compound that has a vital role in various metabolic pathways. Calcium folinate (CF) drug is also used in the treatment of anemia, during pregnancy. |
| Other Notes: |
Sales restrictions may apply. |
| Packaging: |
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Storage Temp. |
2-8°C |
| UNSPSC |
41116107 |
GHS07,GHS08