Cholecalciferol

SIAL/C1357 - meets USP testing specifications

Synonym: (+)-Vitamin D₃; 7-Dehydrocholesterol activated; Activated 7-dehydrocholesterol; Calciol

CAS Number: 67-97-0
Empirical Formula (Hill Notation): C₂₇H₄₄O
Molecular Weight: 384.64
EC Number: 200-673-2
MDL Number: MFCD00078131
Linear Formula: C₂₇H₄₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C1357-250MG	250 mg	$53.30 1/EA	Add To Favorites
45-C1357-1G	1 g	$103.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C1357-25G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
application(s)	pharmaceutical (small molecule)
assay	97.0-103.0%
color	white
form	crystalline
InChI	1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key	QYSXJUFSXHHAJI-YRZJJWOYSA-N
mp	83-86 °C (lit.)
Quality Level	200
SMILES string	CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=CC=C(C[C@@H](O)CC3)/C3=C
storage temp.	2-8°C

Application:	Cholecalciferol has been used: • to induce arterial medial calcification (AMC) in mice • to study its impact in vascular remodeling associated with vascular calcification (VC) in murine model of obesity and insulin resistance (ob/ob mice) • to study its effect on anchorage dependent growth of RWPE2-W99 cells in monolayer culture
Biochem/physiol Actions:	Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Biochem/physiol Actions:	Vitamin D acts through a receptor that modulates the proliferation and differentiation of both normal and cancer cells.
General description:	Cholecalciferol (vitamin D3), a fat-soluble steroid is produced in the skin.
Packaging:	1 g in ampule
Packaging:	25 g in glass bottle
Packaging:	250 mg in ampule

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H372
Precautionary statements	P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
Hazard Codes	T+
Risk Statements	24/25-26-48/25
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97.0-103.0%
mp	83-86 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352205

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