Cisplatin
SIAL/C2210000 - European Pharmacopoeia (EP) Reference Standard
Synonym: cis-Diammineplatinum(II) dichloride; cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin
CAS Number: 15663-27-1
Empirical Formula (Hill Notation): H6Cl2N2Pt
Molecular Weight: 300.05
EC Number: 239-733-8
MDL Number: MFCD00011623
Linear Formula: Pt(NH3)2Cl2
Product Type: Chemical
| API family | cisplatin |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/2ClH.2H3N.Pt/h2*1H;2*1 |
| InChI key | LXZZYRPGZAFOLE-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| mp | 270 °C (lit.) |
| SMILES string | N.N.Cl[Pt]Cl |
| Application: | This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use. Established for the preparation of the below-given solutions as per European Pharmacopoeia:• Reference solutions in the identification using infrared absorption spectroscopy and thin-layer chromatography, testing of related substances, and assay using liquid chromatography (General text 2.2.29) of cisplatin, according to the monograph 0599 • Reference solution (b) for the testing of related substances in carboplatin using liquid chromatography (General text 2.2.29), according to the monograph 1081 |
| Biochem/physiol Actions: | Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 - H315 - H317 - H319 - H334 - H335 - H350 |
| Precautionary statements | P201 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 45-25-41 |
| Safety Statements | 53-26-39-45 |
| RIDADR | UN 3288 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 270 °C (lit.) |
| UNSPSC | 41116107 |