Cholecalciferol

SIAL/C9774 - analytical standard

Synonym: (+)-Vitamin D₃; 7-Dehydrocholesterol activated; Activated 7-dehydrocholesterol; Calciol

CAS Number: 67-97-0
Empirical Formula (Hill Notation): C₂₇H₄₄O
Molecular Weight: 384.64
EC Number: 200-673-2
MDL Number: MFCD00078131
Linear Formula: C₂₇H₄₄O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C9774-1AMP	1 amp	$145.00 1/EA	Add To Favorites
45-C9774-5AMP	5 amp	$554.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.0%
biological source	synthetic (organic - wool)
color	white
form	crystalline
grade	analytical standard
InChI	1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
InChI key	QYSXJUFSXHHAJI-YRZJJWOYSA-N
mp	83-86 °C (lit.)
packaging	pkg of 250 mg
Quality Level	200
SMILES string	CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=CC=C(C[C@@H](O)CC3)/C3=C
storage temp.	2-8°C

Application:	Cholecalciferol has been used as an internal standard in high-performance liquid chromatography (HPLC) to analyze serum vitamin D levels. It has also been used as a standard in liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) to quantify vitamin D3 in sunflower oil.
Application:	Cholecalciferol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.
Biochem/physiol Actions:	Cholecalciferol is sourced either through the diet or exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue. Deficiency of vitamin D is often observed in chronic kidney disease.
Biochem/physiol Actions:	Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
General description:	Cholecalciferol, also called vitamin D₃, promotes the absorption of calcium and phosphorus in the body to regulate bone growth. It is most commonly found in humans and animals and is produced in our skin when exposed to sunlight. It is used to treat and prevent bone disorders (such as rickets, osteomalacia).
Packaging:	1, 5 amp in ampule
Packaging:	Packaged in flame-sealed ampules under Argon

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H372
Precautionary statements	P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
Hazard Codes	T+
Risk Statements	24/25-26-48/25
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0%
mp	83-86 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352200

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