Deferoxamine mesylate salt
SIAL/D0160000 - European Pharmacopoeia (EP) Reference Standard
Synonym: DFOM; Deferoxamine methanesulfonate salt; Desferrioxamine mesylate salt
CAS Number: 138-14-7
Empirical Formula (Hill Notation): C25H48N6O8 · CH4O3S
Molecular Weight: 656.79
MDL Number: MFCD00058605
Linear Formula: C25H48N6O8 · CH4O3S
Product Type: Chemical
API family | deferoxamine |
application(s) | pharmaceutical (small molecule) |
format | neat |
grade | pharmaceutical primary standard |
InChI | 1S/C25H48N6O8.CH4O3S/c1-2 |
InChI key | IDDIJAWJANBQLJ-UHFFFAOYSA |
manufacturer/tradename | EDQM |
SMILES string | CS(O)(=O)=O.CC(=O)N(O)CCC |
Application: | Deferoxamine mesylate salt EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
Biochem/physiol Actions: | An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage. |
General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia . |
Other Notes: | Sales restrictions may apply. |
Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
UNSPSC | 41116107 |