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Daunorubicin hydrochloride

SIAL/D8809 - meets USP testing specifications

Synonym: Daunomycin hydrochloride

CAS Number: 23541-50-6
Empirical Formula (Hill Notation): C27H29NO10 · HCl
Molecular Weight: 563.98
EC Number: 245-723-4
MDL Number: MFCD04974507
Linear Formula: C27H29NO10 · HCl
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-D8809-1MG 1 mg
$63.40
1/EA
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45-D8809-10MG 10 mg
$318.00
1/EA
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D8809-50MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D8809-50MG

 

agency meets USP testing specifications
  USP/NF
antibiotic activity spectrum neoplastics
form solid
InChI 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key GUGHGUXZJWAIAS-QQYBVWGSSA-N
mode of action DNA synthesis | interferes
Quality Level 200 
SMILES string Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
storage temp. 2-8°C
Biochem/physiol Actions: Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis.
Biochem/physiol Actions: Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.
Packaging: 1, 10 mg in glass bottle
Packaging: 50 mg in poly bottle
Storage Temp. 2-8°C
UNSPSC 12352200

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