Daunorubicin hydrochloride
SIAL/D8809 - meets USP testing specifications
Synonym: Daunomycin hydrochloride
CAS Number: 23541-50-6
Empirical Formula (Hill Notation): C27H29NO10 · HCl
Molecular Weight: 563.98
EC Number: 245-723-4
MDL Number: MFCD04974507
Linear Formula: C27H29NO10 · HCl
Product Type: Chemical
agency | meets USP testing specifications |
USP/NF | |
antibiotic activity spectrum | neoplastics |
form | solid |
InChI | 1S/C27H29NO10.ClH/c1-10-2 |
InChI key | GUGHGUXZJWAIAS-QQYBVWGSSA |
mode of action | DNA synthesis | interferes |
Quality Level | 200 ![]() |
SMILES string | Cl.COc1cccc2C(=O)c3c(O)c4 |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis. |
Biochem/physiol Actions: | Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent. |
Packaging: | 1, 10 mg in glass bottle |
Packaging: | 50 mg in poly bottle |
Symbol | ![]() ![]() |
Signal word | Danger |
Hazard statements | H301 - H341 - H351 - H360FD |
Precautionary statements | P201 - P202 - P264 - P270 - P280 - P301 + P310 |
Hazard Codes | Xn |
Risk Statements | 22-40-42/43 |
Safety Statements | 22-36/37-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |