Erythromycin

SIAL/E0774 - meets USP testing specifications

Synonym: Erythromycin A

CAS Number: 114-07-8
Empirical Formula (Hill Notation): C₃₇H₆₇NO₁₃
Molecular Weight: 733.93
EC Number: 204-040-1
MDL Number: MFCD00084654
Linear Formula: C₃₇H₆₇NO₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E0774-5G	5 g	$106.00 1/EA	Add To Favorites
45-E0774-25G	25 g	$403.00 1/EA	Add To Favorites
45-E0774-100G	100 g	$982.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: E0774-100G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
application(s)	pharmaceutical (small molecule)
form	solid
InChI	1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI key	ULGZDMOVFRHVEP-RWJQBGPGSA-N
mode of action	protein synthesis \| interferes
optical activity	[α]/D -78 to --71°
Quality Level	200
SMILES string	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
solubility	ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Application:	Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
Biochem/physiol Actions:	Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex. Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.
Caution:	This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.
General description:	Chemical structure: macrolide
Packaging:	5, 25, 100 g in poly bottle
Preparation Note:	This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51101500

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