(−)-Epigallocatechin
SIAL/E3768 - ≥95% (HPLC), from green tea
Synonym: (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxyflavane
CAS Number: 970-74-1
Empirical Formula (Hill Notation): C15H14O7
Molecular Weight: 306.27
MDL Number: MFCD00075939
Linear Formula: C15H14O7
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E3768-5MG
| assay | ≥95% (HPLC) |
| biological source | green tea |
| InChI | 1S/C15H14O7/c16-7-3-9(17) |
| InChI key | XMOCLSLCDHWDHP-IUODEOHRSA |
| Quality Level | 200  |
| SMILES string | O[C@@H]1Cc2c(O)cc(O)cc2O[ |
| storage temp. | 2-8°C |
| Application: | (−)-Epigallocatechin (EGC) has been used: • as a reference standard in high-performance liquid chromatography (HPLC) analysis • to analyze its inhibitory effect on α-amylase and α-glucosidase activity to control postprandial hyperglycemia in Diabetes mellitus • in cell viability assays to check its efficacy and protection against ferroptosis and iron toxicity in murine pancreatic β-cells • to evaluate its potential anti-inflammatory effects on long-term acute and chronic Pristen-induced arthritis • to treat pregnant and nursing mice, on in vitro angiogenesis, proliferation, and movement of endothelial cells • to evaluate its effect on pregnant and nursing mice spleen based on the number and localization of CD4+ (cluster of differentiation 4) and CD8+ cluster of differentiation 8) cells |
| Biochem/physiol Actions: | (−)-Epigallocatechin (EGC) has proven to be an anti-cancer agent by its inhibitory effects on heregulin-b1 (HRG)-induced migration/invasion in MCF-7 human breast carcinoma cells. It has also shown strong antiviral activity against the herpes simplex virus. |
| Biochem/physiol Actions: | Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG. |
| General description: | (−)-Epigallocatechin is one of the main catechin compounds found in green tea and the most abundant one (~20%), with antioxidant properties. |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |