N-Ethylmaleimide
SIAL/E3876 - crystalline, ≥98% (HPLC)
Synonym: NEM
CAS Number: 128-53-0
Empirical Formula (Hill Notation): C6H7NO2
Molecular Weight: 125.13
EC Number: 204-892-4
MDL Number: MFCD00005509
Linear Formula: C6H7NO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E3876-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E3876-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E3876-5G
| assay | ≥98% (HPLC) |
| biological source | synthetic (organic) |
| bp | 210 °C (lit.) |
| form | crystalline |
| InChI | 1S/C6H7NO2/c1-2-7-5(8)3-4 |
| InChI key | HDFGOPSGAURCEO-UHFFFAOYSA |
| mp | 43-46 °C (lit.) |
| Quality Level | 200  |
| SMILES string | CCN1C(=O)C=CC1=O |
| solubility | ethanol: 50 mg/mL, clear to slightly hazy, colorless to faint yellow or tan |
| storage temp. | 2-8°C |
| Application: | Reagent for the covalent modification of cysteine residues in proteins. |
| Biochem/physiol Actions: | Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. |
| Biochem/physiol Actions: | Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases. |
| Packaging: | 5, 25, 100 g in glass bottle |
| Preparation Note: | NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH. |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H300 - H311 - H314 - H317 |
| Precautionary statements | P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T+ |
| Risk Statements | 21-28-34-43 |
| Safety Statements | 26-28-36/37/39-45 |
| RIDADR | UN 2928 8(6.1) / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 163.2 °F |
| Flash Point(C) | 72.9 °C |
| Purity | ≥98% (HPLC) |
| bp | 210 °C (lit.) |
| mp | 43-46 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |