Flurbiprofen
SIAL/F0285200 - European Pharmacopoeia (EP) Reference Standard
Synonym: (±)-2-Fluoro-α-methyl-4-biphenylacetic acid; L-790,330
CAS Number: 5104-49-4
Empirical Formula (Hill Notation): C15H13FO2
Molecular Weight: 244.26
MDL Number: MFCD00079303
Linear Formula: C6H5C6H3(F)CH(CH3)CO2H
Product Type: Chemical
| API family | flurbiprofen |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C15H13FO2/c1-10(15(17) |
| InChI key | SYTBZMRGLBWNTM-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| mp | 110-112 °C (lit.) |
| SMILES string | CC(C(O)=O)c1ccc(c(F)c1)-c |
| storage temp. | 2-8°C |
| Application: | Flurbiprofen EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
| Biochem/physiol Actions: | Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 110-112 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |