Folinic acid calcium salt hydrate
SIAL/F7878 - analytical standard
Synonym: 5-
CAS Number: 1492-18-8 (anhydrous)
Empirical Formula (Hill Notation): C20H21CaN7O7 · xH2O
Molecular Weight: 511.50 (anhydrous basis)
Linear Formula: C20H21CaN7O7 · xH2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-500MG
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| assay | ≥90.0% |
| biological source | synthetic (organic) |
| color | yellow to orange |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C20H23N7O7.Ca/c21-20-2 |
| InChI key | KVUAALJSMIVURS-ZEDZUCNESA |
| mp | 240-250 °C |
| Quality Level | 100  |
| SMILES string | [Ca++].[H]O[H].[H]C(=O)N1 |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
| Application: | Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry. |
| Application: | Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| General description: | Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues. |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 500 mg in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315 - H317 - H319 - H334 - H335 |
| Precautionary statements | P261 - P264 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 22-26-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90.0% |
| mp | 240-250 °C |
| UNSPSC | 41116107 |