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Folinic acid calcium salt hydrate

SIAL/F7878 - analytical standard

Synonym: 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt; 5-HCO-H4PteGlu; Calcium folinate; Citrovorum factor calcium salt; Leucovorin calcium salt

CAS Number: 1492-18-8 (anhydrous)
Empirical Formula (Hill Notation): C20H21CaN7O7 · xH2O
Molecular Weight: 511.50 (anhydrous basis)
MDL Number: MFCD00149463
Linear Formula: C20H21CaN7O7 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F7878-100MG 100 mg
 $110.00
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45-F7878-500MG 500 mg
 $357.00
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45-F7878-1G 1 g
 $672.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F7878-500MG

 

application(s) forensics and toxicology
pharmaceutical (small molecule)
assay ≥90.0%
biological source synthetic (organic)
color yellow to orange
format neat
grade analytical standard
InChI 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
InChI key KVUAALJSMIVURS-ZEDZUCNESA-L
mp 240-250 °C
Quality Level 100 
SMILES string [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
technique(s) gas chromatography (GC): suitable
  HPLC: suitable
Application: Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Application: Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.
Application: Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.
Application: Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description: Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.
Packaging: 1 g in glass bottle
Packaging: 100, 500 mg in glass bottle
Purity ≥90.0%
mp 240-250 °C
UNSPSC 41116107

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