Gentamicin sulfate salt
SIAL/G3632 - potency: ≥590 I.U. Gentamicin base per mg
CAS Number: 1405-41-0
EC Number: 215-778-9
MDL Number: MFCD00270181
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
mycoplasma | |
biological source | Micromonospora purpurea |
color | white to off-white |
concentration | 50 μg/mL in H2O (is the recommended working concentration for eukaryotic cell culture) |
form | powder |
InChI | 1S/C21H43N5O7.C20H41N5O7. |
InChI key | RDEIXVOBVLKYNT-HDZPSJEVSA |
mode of action | protein synthesis | interferes |
potency | ≥590 I.U. Gentamicin base per mg |
Quality Level | 300 ![]() |
SMILES string | O=S(O)(O)=O.O[C@]1(C)[C@@ |
storage temp. | 2-8°C |
Application: | Gentamicin sulfate, a broad-spectrum antibiotic, used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L. |
Biochem/physiol Actions: | Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus. |
Caution: | Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142. |
Components: | Freely soluble in water, practically insoluble in ethanol |
Components: | Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base. |
General description: | Chemical structure: aminoglycoside |
Packaging: | 1, 5, 10, 25, 100 g in glass bottle |
Packaging: | 250 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H317 |
Precautionary statements | P280 - P302 + P352 |
Hazard Codes | Xn |
Risk Statements | 42/43 |
Safety Statements | 22-36/37-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |