Guanidine thiocyanate
SIAL/G6639 - ≥97% (titration)
Synonym: Guanidinium rhodanide; Guanidinium thiocyanate
CAS Number: 593-84-0
Empirical Formula (Hill Notation): CH5N3 · CHNS
Molecular Weight: 118.16
EC Number: 209-812-1
MDL Number: MFCD00013027
Linear Formula: NH2C(=NH)NH2 · HSCN
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G6639-100G
This image depicts SKU: G6639-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G6639-1KG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G6639-250G
This image depicts SKU: G6639-250G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: G6639-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G6639-1KG
This image depicts SKU: G6639-1KG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SKU: G6639-25G
This image depicts SKU: G6639-25G
| anion traces | chloride (Cl-): ≤2.5% |
| assay | ≥97% (titration) |
| biological source | synthetic |
| color | white to off-white |
| form | powder or crystals |
| InChI | 1S/CH5N3.CHNS/c2-1(3)4;2- |
| InChI key | ZJYYHGLJYGJLLN-UHFFFAOYSA |
| mp | 120-122 °C (lit.) |
| Quality Level | 200  |
| SMILES string | SC#N.NC(N)=N |
| solubility | water: 4 M, clear, colorless |
| technique(s) | RNA extraction: suitable |
| Application: | Chaotropic agent and strong denaturant; solubilizes cells. |
| Application: | Guanidine thiocyanate has been used: • as a denaturing agent to study its effects on surface activity of globular protein • for the extraction of total RNA from primary hepatocytes • as a component of the incubating buffer for extraction of DNA from human bone • as a component of the guanidine thiocyanate (GITC) lysis buffer for extraction of elephant shark DNA • as a component of lysis solution for extraction of RNA from rat pancreatic tissues |
| Biochem/physiol Actions: | Guanidine thiocyanate (GTC) is a powerful protein denaturant and can denature endogenous ribonucleases. It plays a role in separation of ribosomal ribonucleic acid (rRNA) from ribosomes. GTC in combination with phenol and chloroform can be used in isolation of total RNA from cells and tissues. |
| Packaging: | 1 kg in glass bottle |
| Packaging: | 25, 100, 250 g in poly bottle |
| Packaging: | 500 g in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 + H312 + H332 - H314 - H412 |
| Precautionary statements | P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | C,Xn |
| Risk Statements | 20/21/22-32-34-52/53 |
| Safety Statements | 13-26-36/37/39-45-61 |
| RIDADR | UN 1759 8 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Supplemental Hazard Statements | EUH032 |
| Purity | ≥97% (titration) |
| mp | 120-122 °C (lit.) |
| UNSPSC | 12352209 |