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Isoniazid

SIAL/I0500000 - European Pharmacopoeia (EP) Reference Standard

Synonym: 4-Pyridinecarboxylic acid hydrazide; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

CAS Number: 54-85-3
Empirical Formula (Hill Notation): C6H7N3O
Molecular Weight: 137.14
MDL Number: MFCD00006426
Linear Formula: C6H7N3O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I0500000 100 mg
 $153.00
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agency EP Reference Standard
API family isoniazid
application(s) pharmaceutical (small molecule)
format neat
grade pharmaceutical primary standard
InChI 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChI key QRXWMOHMRWLFEY-UHFFFAOYSA-N
manufacturer/tradename EDQM
mp 171-173 °C (lit.)
SMILES string NNC(=O)c1ccncc1
storage temp. 2-8°C
Application: Isoniazid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions: Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.
General description: This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes: Sales restrictions may apply.
Packaging: The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .
mp 171-173 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 41116107

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