Isoniazid
SIAL/I3377 - analytical standard, ≥99% (TLC)
Synonym: 4-Pyridinecarboxylic acid hydrazide; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
CAS Number: 54-85-3
Empirical Formula (Hill Notation): C6H7N3O
Molecular Weight: 137.14
EC Number: 200-214-6
MDL Number: MFCD00006426
Linear Formula: C6H7N3O
Product Type: Chemical
| antibiotic activity spectrum | mycobacteria |
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| assay | ≥99% (TLC) |
| fluorescence | λex 360 nm; λem 450 nm (thiol adduct) |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C6H7N3O/c7-9-6(10)5-1- |
| InChI key | QRXWMOHMRWLFEY-UHFFFAOYSA |
| mp | 171-173 °C (lit.) |
| Quality Level | 100  |
| SMILES string | NNC(=O)c1ccncc1 |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support. |
| Biochem/physiol Actions: | Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. |
| General description: | Chemical structure: pyridine |
| General description: | Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis. |
| Packaging: | 5, 50, 250 g in poly bottle |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 |
| Precautionary statements | P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-38 |
| Safety Statements | 26-37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥99% (TLC) |
| mp | 171-173 °C (lit.) |
| UNSPSC | 41116107 |