Kanamycin sulfate from Streptomyces kanamyceticus

SIAL/K1637 - meets USP testing specifications, powder

Synonym: Kanamycin A; Kanamycin sulfate salt

CAS Number: 25389-94-0
Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · H₂O₄S
Molecular Weight: 582.58
EC Number: 246-933-9
MDL Number: MFCD00070253
Linear Formula: C₁₈H₃₆N₄O₁₁ · H₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K1637-1G	1 g	$64.40 1/EA	Add To Favorites
45-K1637-5G	5 g	$197.00 1/EA	Add To Favorites
45-K1637-25G	25 g	$668.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: K1637-25G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
application(s)	pharmaceutical (small molecule)
biological source	Streptomyces kanamyceticus
form	powder
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N
mode of action	protein synthesis \| interferes
potency	≥750 μg per mg
Quality Level	200
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
solubility	H₂O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)
storage condition	(Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible )

Application:	Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used: in the research of cell type-specific expression of genes
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Features and Benefits:	• High quality antibiotic suitable for mulitple research applications • meets USP testing specifications
General description:	Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic purified from the bacterium Streptomyces kanamyceticus. Kanamycin Sulfate is a selection agent for cells in culture media and acts by binding to the 30S subunit of the bacterial ribosome which inhibits protein synthesis in susceptible bacteria.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Packaging:	1, 5, 25 g in poly bottle
Preparation Note:	Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter. Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

UNSPSC

51101500

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