Kanamycin sulfate from Streptomyces kanamyceticus

SIAL/K1637 - meets USP testing specifications, powder

Synonym: Kanamycin A; Kanamycin sulfate salt

CAS Number: 25389-94-0
Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · H₂O₄S
Molecular Weight: 582.58
EC Number: 246-933-9
MDL Number: MFCD00070253
Linear Formula: C₁₈H₃₆N₄O₁₁ · H₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K1637-1G	1 g	$64.40 1/EA	Add To Favorites
45-K1637-5G	5 g	$197.00 1/EA	Add To Favorites
45-K1637-25G	25 g	$668.00 1/EA	Add To Favorites

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This image depicts SKU: K1637-25G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
application(s)	pharmaceutical (small molecule)
biological source	Streptomyces kanamyceticus
form	powder
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N
mode of action	protein synthesis \| interferes
potency	≥750 μg per mg
Quality Level	300
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
solubility	H₂O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

Application:	Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Caution:	Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
General description:	Chemical structure: aminoglycoside
Packaging:	1, 5, 25 g in poly bottle
Preparation Note:	Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

UNSPSC

51101500

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