Kanamycin sulfate from Streptomyces kanamyceticus

SIAL/K4000 - Animal Component-free

Synonym: Kanamycin A; Kanamycin sulfate salt

CAS Number: 25389-94-0
Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · H₂O₄S
Molecular Weight: 582.58
EC Number: 246-933-9
MDL Number: MFCD00070253
Linear Formula: C₁₈H₃₆N₄O₁₁ · H₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K4000-1G	1 g	$34.10 1/EA	Add To Favorites
45-K4000-5G	5 g	$92.40 1/EA	Add To Favorites
45-K4000-25G	25 g	$393.00 1/EA	Add To Favorites
45-K4000-50G	50 g	$581.00 1/EA	Add To Favorites

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This image depicts SKU: K4000-50G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
biological source	Streptomyces kanamyceticus
color	white to off-white
form	powder
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N
mode of action	protein synthesis \| interferes
potency	≥750 μg per mg (dry basis)
Quality Level	200
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
solubility	H₂O: 50 mg/mL, clear, colorless to faintly yellow

Application:	Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:• in the research of bacterial antibiotic resistance • in the research on the effect of different antibiotics on bud regeneration
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Features and Benefits:	High quality antibiotic suitable for mulitple research applications
General description:	Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Packaging:	1, 5, 25, 50 g in poly bottle
Preparation Note:	Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Preparation Note:	Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter. Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360D
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2

UNSPSC

51281654

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