Metformin hydrochloride
SIAL/M0605000 - European Pharmacopoeia (EP) Reference Standard
Synonym: 1,1-
CAS Number: 1115-70-4
Empirical Formula (Hill Notation): C4H11N5 · HCl
Molecular Weight: 165.62
MDL Number: MFCD00012582
Linear Formula: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Product Type: Chemical
| agency | EP Reference standard |
| API family | metformin |
| application(s) | pharmaceutical (small molecule) |
| format | neat |
| grade | pharmaceutical primary standard |
| InChI | 1S/C4H11N5.ClH/c1-9(2)4(7 |
| InChI key | OETHQSJEHLVLGH-UHFFFAOYSA |
| manufacturer/tradename | EDQM |
| mp | 223-226 °C (lit.) |
| SMILES string | Cl[H].CN(C)C(=N)NC(N)=N |
| Application: | Metformin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia. |
| Biochem/physiol Actions: | Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines. |
| General description: | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia   . |
| Other Notes: | Sales restrictions may apply. |
| Packaging: | The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| mp | 223-226 °C (lit.) |
| UNSPSC | 41116107 |