Neomycin trisulfate salt hydrate

SIAL/N5285 - meets USP testing specifications, powder

Synonym: Framycetin sulfate; Neomycin Sulfate

CAS Number: 1405-10-3
Empirical Formula (Hill Notation): C₂₃H₄₆N₆O₁₃ · 3H₂SO₄ · xH₂O
Molecular Weight: 908.88 (anhydrous basis)
EC Number: 215-773-1
Linear Formula: C₂₃H₄₆N₆O₁₃ · 3H₂SO₄ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N5285-25G	25 g	$94.90 1/EA	Add To Favorites
45-N5285-100G	100 g	$283.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N5285-100G

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
application(s)	pharmaceutical (small molecule)
form	powder
InChI	1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;31-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1
InChI key	WHAGUNPVKDUVFV-QGTTWHFQSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O
solubility	H₂O: 50 mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.)

Application:	Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins. It is recommended for use in cell culture applications at 50 mg/L.
Biochem/physiol Actions:	Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons. Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria.
Caution:	Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
Packaging:	25, 100 g in glass bottle
Preparation Note:	Neomycin sulfate is soluble in H₂O at 50 mg/mL, yielding a clear solution.

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P342 + P311
Hazard Codes	Xi
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

51101500

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