Nicotinic acid
SIAL/N5410 - meets USP testing specifications
Synonym: 3-Picolinic acid; Niacin; Pellagra preventive factor; Pyridine-
CAS Number: 59-67-6
Empirical Formula (Hill Notation): C6H5NO2
Molecular Weight: 123.11
EC Number: 200-441-0
MDL Number: MFCD00006391
Linear Formula: C6H5NO2
Product Type: Chemical
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This image depicts SKU: N5410-100G
This image depicts SKU: N5410-100G
| agency | meets USP testing specifications |
| USP/NF | |
| application(s) | pharmaceutical (small molecule) |
| assay | 99.0-101.0% dry basis |
| biological source | synthetic (organic) |
| color | white |
| form | powder |
| InChI | 1S/C6H5NO2/c8-6(9)5-2-1-3 |
| InChI key | PVNIIMVLHYAWGP-UHFFFAOYSA |
| mp | 236-239 °C (lit.) |
| Quality Level | 200  |
| SMILES string | OC(=O)c1cccnc1 |
| Application: | Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity. |
| Biochem/physiol Actions: | Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels. |
| General description: | Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P280 - P305 + P351 + P338 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 379.4 °F - closed cup |
| Flash Point(C) | 193 °C - closed cup |
| Purity | 99.0-101.0% dry basis |
| mp | 236-239 °C (lit.) |
| UNSPSC | 12352200 |