β-Nicotinamide adenine dinucleotide hydrate

SIAL/N7004 - ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

Synonym: β-DPN; β-NAD; Coenzyme 1; Cozymase; DPN; Diphosphopyridine nucleotide; NAD; Nadide

CAS Number: 53-84-9
Empirical Formula (Hill Notation): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
Molecular Weight: 663.43 (anhydrous basis)
MDL Number: MFCD00036253
Linear Formula: C₂₁H₂₇N₇O₁₄P₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N7004-250MG	250 mg	$39.20 1/EA	Add To Favorites
45-N7004-1G	1 g	$106.00 1/EA	Add To Favorites
45-N7004-5G	5 g	$371.00 1/EA	Add To Favorites
45-N7004-10G	10 g	$621.00 1/EA	Add To Favorites
45-N7004-25G	25 g	$1290.00 1/EA	Add To Favorites
45-N7004-100G	100 g	$4200.00 1/EA	Add To Favorites

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This image depicts SKU: N7004-25G

12 Principles of Green Chemistry: Principle 1—Waste Prevention. This product has a smaller environmental footprint through reduction of waste in the manufacturing process.

12 Principles of Green Chemistry: Principle 3—Less Hazardous Chemical Syntheses. This product manufacturing process was designed with lesser toxicity to human health and the environment.

12 Principles of Green Chemistry: Principle 5—Safer Solvents and Auxiliaries. This product utilizes reduced volumes of auxiliary substances that are less hazardous.

12 Principles of Green Chemistry: Principle 7—A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable.

12 Principles of Green Chemistry: Principle 12—Inherently Safer Chemistry for Accident Prevention. This product utilizes safer chemistry to minimize the potential for chemical accidents, including releases, explosions and fires.

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics
assay	≥96.5% (HPLC)
	≥96.5% (spectrophotometric assay)
biological source	yeast
color	white to off-white
form	powder
greener alternative category	Re-engineered ,
greener alternative product characteristics	Waste Prevention Less Hazardous Chemical Syntheses Safer Solvents and Auxiliaries Design for Energy Efficiency Use of Renewable Feedstocks Inherently Safer Chemistry for Accident Prevention Learn more about the Principles of Green Chemistry .
greener alternative product score	old score: 56 new score: 20 Find out more about DOZN™ Scoring
InChI	1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChI key	BAWFJGJZGIEFAR-NNYOXOHSSA-N
Quality Level	300
SMILES string	NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
storage temp.	−20°C
sustainability	Greener Alternative Product

Application:	β-Nicotinamide adenine dinucleotide hydrate has been used:• to prepare NAD+ standard solution for a study on NAD+ metabolomics • as a component of MurI assay reaction partial mixture for glutamate racemase reaction • as a component of a chromogenic staining solution to stain zebrafish embryos
Biochem/physiol Actions:	Electron acceptor
Features and Benefits:	Versatile and adaptable for a wide variety of laboratory and research applications.
General description:	Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme that transcends its traditional role as an "electron carrier," influencing diverse cellular processes. In cell biology, NAD operates as a crucial electron acceptor in the electron transport chain, driving the production of ATP, the cell′s primary energy source. This electron flow sustains basic cellular maintenance and complex signaling pathways. Beyond its energetic role, NAD serves as a dynamic signaling molecule, dictating cellular responses to various stimuli. Fluctuations in NAD concentration trigger events in DNA repair, gene expression, and cell death, allowing cells to adapt to stress and maintain homeostasis. In biochemical research, NAD emerges as a vital cofactor for enzymes like sirtuins, poly(ADP-ribose) polymerases, and cADP-ribose synthases. These enzymes rely on NAD+ for catalytic activity, influencing processes such as protein deacetylation, DNA repair, and cellular signaling. In metabolomics, NAD plays a key role in metabolic pathways, making it a significant focus for understanding cellular metabolism comprehensively. NAD participates in additional intricate cellular processes, serving as a substrate for ADP-ribosylation—a post-translational modification affecting protein function. It also acts as a precursor for cyclic ADP-ribose, a second messenger molecule involved in calcium mobilization and cell communication. Research on NAD holds promise across various areas, including aging, where its role is actively investigated. Studies also explore its implications in neurodegenerative disorders and metabolic imbalances.
General description:	We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency”, “Use of Renewable Feedstocks” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Other Notes:	This is the common form of NAD.
Packaging:	1, 5, 10, 25 g in poly bottle
Packaging:	250 mg in poly bottle
Packaging:	Packaged by solid weight.
Preparation Note:	To prepare a solution gentle heating and sonication may be necessary.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥96.5% (HPLC); ≥96.5% (spectrophotometric assay)
Storage Temp.	−20°C
UNSPSC	41106305

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