Pefloxacin mesilate dihydrate

SIAL/P0309000 - European Pharmacopoeia (EP) Reference Standard

Synonym: Pefloxacin mesylate dihydrate; 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate; Pefloxacine monomethanesulfonate dihydrate; Pefloxacinium methanesulfonate dihydrate

CAS Number: 149676-40-4
Empirical Formula (Hill Notation): C₁₈H₂₈FN₃O₈S
Molecular Weight: 465.49
MDL Number: MFCD01685696
Linear Formula: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0309000	200 mg	$156.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

API family	pefloxacin
application(s)	pharmaceutical (small molecule)
format	neat
grade	pharmaceutical primary standard
InChI	1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChI key	LEULAXMUNMRLPW-UHFFFAOYSA-N
manufacturer/tradename	EDQM
SMILES string	O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
storage temp.	2-8°C

Application:	Pefloxacin mesilate dihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions:	Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.
Biochem/physiol Actions:	Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin. Mode of Action: Pefloxacin prevents bacterial DNA replication by inhibiting DNA gyrase. Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa. Active against gram-positive bacteria and excellent activity against gram-negative bacteria.
General description:	This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia .
Other Notes:	Sales restrictions may apply.
Packaging:	The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue .

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264 - P280 - P305 + P351 + P338 - P337 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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