Polymyxin B sulfate

SIAL/P0972 - meets USP testing specifications

Synonym: Polymyxin B sulfate salt

CAS Number: 1405-20-5
Empirical Formula (Hill Notation): C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
Molecular Weight: 1385.61
EC Number: 215-774-7
MDL Number: MFCD00131991
Linear Formula: C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P0972-1MU	1000000 units	$83.10 1/EA		Add To Favorites
45-P0972-10MU	10000000 units	$412.00 1/EA		Add To Favorites
45-P0972-50MU	50000000 units	$1460.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
antibiotic activity spectrum	fungi
	Gram-negative bacteria
	Gram-positive bacteria
application(s)	pharmaceutical (small molecule)
form	powder
InChI	1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key	HNDFYNOVSOOGDU-UHFFFAOYSA-N
mode of action	cell membrane \| interferes
Quality Level	200
SMILES string	O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
storage temp.	2-8°C

Application:	Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem/physiol Actions:	Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Caution:	As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
General description:	Chemical structure: peptide
Packaging:	This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 - P501
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352209

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