Polymyxin B sulfate salt
SIAL/P1004
Synonym: Polymixin; Polymixin B; Polymixin B sulfate
CAS Number: 1405-20-5
Empirical Formula (Hill Notation): C55H96N16O13 · 2H2SO4
Molecular Weight: 1385.61
EC Number: 215-774-7
MDL Number: MFCD00131991
Linear Formula: C55H96N16O13 · 2H2SO4
Product Type: Chemical
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This image depicts SKU: P1004-50MU
This image depicts SKU: P1004-50MU
| antibiotic activity spectrum | fungi |
| Gram-negative bacteria | |
| biological source | Pseudomonas aeruginosa |
| form | powder |
| InChI | 1S/C48H82N16O13.H2O4S/c1- |
| InChI key | HNDFYNOVSOOGDU-UHFFFAOYSA |
| mode of action | cell membrane | interferes |
| Quality Level | 200  |
| SMILES string | O=C(C(NC(C(CCN)NC(CCCCC(C |
| solubility | water: 50 mg/mL |
| storage condition | ( |
| storage temp. | 2-8°C |
| Application: | Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. |
| Application: | Polymyxin B sulfate salt has been used: • in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin • in the analysis of the isolates • in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay) |
| Biochem/physiol Actions: | Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria. |
| Biochem/physiol Actions: | Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. |
| Features and Benefits: | High quality antibiotic suitable for mulitple research applications |
| General description: | Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. |
| Packaging: | 1000000, 5000000, 10000000, 25000000, 50000000 units in poly bottle |
| Preparation Note: | Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days. |
| Storage and Stability: | As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 51101500 |