Polymyxin B sulfate salt

SIAL/P1004

CAS Number: 1405-20-5
Empirical Formula (Hill Notation): C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
Molecular Weight: 1385.61
EC Number: 215-774-7
MDL Number: MFCD00131991
Linear Formula: C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P1004-1MU	1000000 units	$55.90 1/EA	Add To Favorites
45-P1004-5MU	5000000 units	$153.00 1/EA	Add To Favorites
45-P1004-10MU	10000000 units	$237.00 1/EA	Add To Favorites
45-P1004-25MU	25000000 units	$475.00 1/EA	Add To Favorites
45-P1004-50MU	50000000 units	$817.00 1/EA	Add To Favorites

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This image depicts SKU: P1004-50MU

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-negative bacteria
form	powder
InChI	1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key	HNDFYNOVSOOGDU-UHFFFAOYSA-N
mode of action	cell membrane \| interferes
Quality Level	200
storage temp.	2-8°C

Application:	Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Application:	Polymyxin B sulfate salt has been used: • in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin • in the analysis of the isolates • in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)
Biochem/physiol Actions:	Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Biochem/physiol Actions:	Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae.
Caution:	As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
General description:	Chemical structure: peptide
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	1000000, 5000000, 10000000, 25000000, 50000000 units in poly bottle
Preparation Note:	Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51101500

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