Cucurbitacin E
SIAL/PHL80013 - phyproof® Reference Substance
Synonym: α-Elaterin; α-Elaterine
CAS Number: 18444-66-1
Empirical Formula (Hill Notation): C32H44O8
Molecular Weight: 556.69
Linear Formula: C32H44O8
Product Type: Chemical
| application(s) | food and beverages |
| assay | ≥95.0% (HPLC) |
| format | neat |
| grade | primary reference standard |
| InChI | 1S/C32H44O8/c1-17(33)40-2 |
| InChI key | NDYMQXYDSVBNLL-MUYMLXPFSA |
| manufacturer/tradename | PhytoLab |
| product line | phyproof® Reference Substance |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation. |
| General description: | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG. |
| Legal Information: | phyproof is a registered trademark of PhytoLab GmbH & Co. KG |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95.0% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |