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Homoharringtonine

SIAL/PHL89708 - phyproof® Reference Substance

Synonym: Ceflatonin; Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate; Myelostat; NSC 141633; Omacetaxine mepesuccinate

CAS Number: 26833-87-4
Empirical Formula (Hill Notation): C29H39NO9
Molecular Weight: 545.62
MDL Number: MFCD03410264
Linear Formula: C29H39NO9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PHL89708-10MG 10 mg
 $288.00
1/EA		 Add To Favorites

 

application(s) food and beverages
assay ≥95.0% (HPLC)
format neat
grade primary reference standard
InChI 1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChI key HYFHYPWGAURHIV-JFIAXGOJSA-N
manufacturer/tradename PhytoLab
product line phyproof® Reference Substance
SMILES string COC(=O)C[C@](O)(CCCC(C)(C)O)C(=O)O[C@H]1C2c3cc4OCOc4cc3CCN5CCC[C@]25C=C1OC
storage temp. −20°C
Biochem/physiol Actions: Homoharringtonine (Omacetaxine mepesuccinate) is a translation elongation inhibitor, a cytotoxic alkaloid originally isolated from the evergreen tree, Cephalotaxus hainanensis. Homoharringtonine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. Homoharringtonine blocks progression of leukemic cells from G1 phase into S phase and from G2 phase into M phase. Homoharringtonine (Omacetaxine mepesuccinate) was approved in October 2012 (Synribo) for the treatment of adult patients with Chronic Myelogenous Leukemia (CML) with resistance and/or intolerance to two or more tyrosine kinase inhibitors.
General description: This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Legal Information: phyproof is a registered trademark of PhytoLab GmbH & Co. KG
Purity ≥95.0% (HPLC)
Storage Temp. −20°C
UNSPSC 41116107

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