Aspirin (Acetyl Salicylic Acid)
SIAL/PHR1003 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Acetylsalicylic acid; 2-Acetoxybenzoic acid; O-Acetylsalicylic acid; ASA; Aspirin
CAS Number: 50-78-2
Empirical Formula (Hill Notation): C9H8O4
Molecular Weight: 180.16
EC Number: 200-064-1
MDL Number: MFCD00002430
Linear Formula: 2-(CH3CO2)C6H4CO2H
Product Type: Chemical
| agency | traceable to BP 617 |
| traceable to Ph. Eur. A0200000 | |
| traceable to USP 1044006 | |
| API family | aspirin |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C9H8O4/c1-6(10)13-8-5- |
| InChI key | BSYNRYMUTXBXSQ-UHFFFAOYSA |
| mp | 134-136 °C (lit.) |
| Quality Level | 300  |
| SMILES string | CC(=O)Oc1ccccc1C(O)=O |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Aspirin (Acetyl Salicylic Acid) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors. |
| Biochem/physiol Actions: | Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB7669 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Aspirin (Acetyl Salicylic Acid) is a cyclo-oxygenase inhibitor and an antiplatelet agent, widely used for the secondary preventions of heart attack and stroke. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 + P330 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 482.0 °F |
| Flash Point(C) | 250 °C |
| mp | 134-136 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |