Hydrocortisone
SIAL/PHR1014 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 17-
CAS Number: 50-23-7
Empirical Formula (Hill Notation): C21H30O5
Molecular Weight: 362.46
EC Number: 200-020-1
MDL Number: MFCD00011654
Linear Formula: C21H30O5
Product Type: Chemical
| agency | traceable to BP 576 |
| traceable to Ph. Eur. H1300000 | |
| traceable to USP 1316004 | |
| API family | hydrocortisone |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C21H30O5/c1-19-7-5-13( |
| InChI key | JYGXADMDTFJGBT-VWUMJDOOSA |
| mp | 211-214 °C (lit.) |
| Quality Level | 300  |
| SMILES string | [H][C@@]12CCC3=CC(=O)CC[C |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency. |
| Biochem/physiol Actions: | Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H360Df - H373 |
| Precautionary statements | P202 - P260 - P280 - P308 + P313 - P405 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 63 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 211-214 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |