Theophylline
SIAL/PHR1023 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 1,3-Dimethylxanthine; 2,6-
CAS Number: 58-55-9
Empirical Formula (Hill Notation): C7H8N4O2
Molecular Weight: 180.16
EC Number: 200-385-7
MDL Number: MFCD00079619
Linear Formula: C7H8N4O2
Product Type: Chemical
| agency | traceable to BP 327 |
| traceable to Ph. Eur. T080000 | |
| traceable to USP 1653004 | |
| API family | theophylline |
| application(s) | food and beverages pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C7H8N4O2/c1-10-5-4(8-3 |
| InChI key | ZFXYFBGIUFBOJW-UHFFFAOYSA |
| Quality Level | 300  |
| SMILES string | CN1C(=O)N(C)c2[nH]cnc2C1= |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Theophylline may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by chromatography and spectrophotometry. |
| Application: | Theophylline may be used as a reference standard in determining the concentration of theophylline present in beverages, food and herbal products using high performance liquid chromatography (HPLC). |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA7171 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards |
| General description: | Theophylline is a methylxanthine drug, most widely prescribed for the management of asthma and chronic obstructive pulmonary disease (COPD). |
| General description: | Theophylline is a xanthine derivative, which is widely found in human diet. It occurs abundantly in chocolate food products. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |