Diethylene glycol
SIAL/PHR1045 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: DEG; 2,2′-Oxydiethanol; 2-Hydroxyethyl ether; Bis(2-hydroxyethyl) ether; Diglycol
CAS Number: 111-46-6
Empirical Formula (Hill Notation): C4H10O3
Molecular Weight: 106.12
EC Number: 203-872-2
MDL Number: MFCD00002882
Linear Formula: (HOCH2CH2)2O
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0000217 |
| traceable to USP 1193265 | |
| application(s) | cleaning products cosmetics food and beverages personal care pharmaceutical (small molecule) |
| autoignition temp. | 442 °F |
| bp | 245 °C (lit.) |
| CofA | current certificate can be downloaded |
| density | 1.118 g/mL at 25 °C (lit.) |
| expl. lim. | 2-12.3 % |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C4H10O3/c5-1-3-7-4-2-6 |
| InChI key | MTHSVFCYNBDYFN-UHFFFAOYSA |
| mp | −10 °C (lit.) |
| Quality Level | 300  |
| refractive index | n |
| SMILES string | OCCOCCO |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor density | 2.14 (vs air) |
| vapor pressure | 0.01 mmHg ( 20 °C) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC). |
| Application: | Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID). |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 46 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 280.4 °F - closed cup |
| Flash Point(C) | 138 °C - closed cup |
| bp | 245 °C (lit.) |
| mp | −10 °C (lit.) |
| Density | 1.118 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |