Famotidine
SIAL/PHR1055 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: {3-
CAS Number: 76824-35-6
Empirical Formula (Hill Notation): C8H15N7O2S3
Molecular Weight: 337.45
MDL Number: MFCD00079297
Linear Formula: C8H15N7O2S3
Product Type: Chemical
| agency | BP |
| EP | |
| traceable to BP 653 | |
| traceable to Ph. Eur. F0050000 | |
| traceable to USP 1269200 | |
| USP | |
| API family | famotidine |
| application(s) | pharmaceutical (small molecule) |
| biological source | synthetic |
| CofA | current certificate can be downloaded |
| color | white to pale yellow-white |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C8H15N7O2S3/c9-6(15-20 |
| InChI key | XUFQPHANEAPEMJ-UHFFFAOYSA |
| mp | 325.4-327.2 °F (163—164°C) |
| packaging | pkg of 1 g |
| Quality Level | 300  |
| shipped in | ambient |
| SMILES string | NC(N)=Nc1nc(CSCCC(=N)NS |
| solubility | acetone: practically insoluble |
| chloroform: practically insoluble | |
| DMF: freely soluble | |
| ethanol: practically insoluble | |
| ether: practically insoluble | |
| ethyl acetate: practically insoluble | |
| glacial acetic acid: freely soluble | |
| methanol: slightly soluble | |
| water: very slightly soluble | |
| storage condition | protect from light (20 mm aluminium crimp seal for unused portion) |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor pressure | <0.0000001 kPa ( 25 °C) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Famotidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | H2 histamine receptor antagonist; anti-ulcer agent |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA7133 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 325.4-327.2 °F (163—164°C) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |