Furosemide
SIAL/PHR1057 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: FUR; 4-Chloro-N-
CAS Number: 54-31-9
Empirical Formula (Hill Notation): C12H11ClN2O5S
Molecular Weight: 330.74
EC Number: 200-203-6
MDL Number: MFCD00010549
Linear Formula: C12H11ClN2O5S
Product Type: Chemical
| agency | traceable to Ph. Eur. F0700000 |
| traceable to USP 1287008 | |
| API family | furosemide |
| application(s) | forensics and toxicology pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C12H11ClN2O5S/c13-9-5- |
| InChI key | ZZUFCTLCJUWOSV-UHFFFAOYSA |
| mp | 220 °C (dec.) (lit.) |
| Quality Level | 300  |
| SMILES string | NS(=O)(=O)c1cc(C(O)=O)c(N |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available. |
| Application: | Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy. |
| Application: | Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC). |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Inhibits ion co-transport in the kidney. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension. |
| Other Notes: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Other Notes: | To see an example of a Certificate of Analysis for this material enter LRAA7130 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H360FD |
| Precautionary statements | P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 61 |
| Safety Statements | 53-22-36/37/39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| mp | 220 °C (dec.) (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |