Metformin hydrochloride
SIAL/PHR1084 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 1,1-
CAS Number: 1115-70-4
Empirical Formula (Hill Notation): C4H11N5 · HCl
Molecular Weight: 165.62
EC Number: 214-230-6
MDL Number: MFCD00012582
Linear Formula: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Product Type: Chemical
| agency | traceable to Ph. Eur. M0605000 |
| traceable to USP 1396309 | |
| API family | metformin |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C4H11N5.ClH/c1-9(2)4(7 |
| InChI key | OETHQSJEHLVLGH-UHFFFAOYSA |
| mp | 223-226 °C (lit.) |
| packaging | pkg of 500 mg |
| Quality Level | 300  |
| SMILES string | Cl[H].CN(C)C(=N)NC(N)=N |
| storage temp. | 2-30°C |
| 2-8°C | |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Metformin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines. |
| Footnote: | For chromatography information for this material, please follow the link:https://www.sigmaaldrich. |
| General description: | Metformin is a biguanide hypoglycaemic agent and an oral antidiabetic medication widely used in the treatment of type 2 diabetes. It is effective in glycemic control and decreases the intestinal absorption of glucose, without the problem of serious lactic acidosis. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| mp | 223-226 °C (lit.) |
| Storage Temp. | 2-30°C; 2-8°C |
| UNSPSC | 41116107 |