N-Acetyl-L-cysteine

SIAL/PHR1098 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: LNAC; NAC

CAS Number: 616-91-1
Empirical Formula (Hill Notation): C₅H₉NO₃S
Molecular Weight: 163.19
EC Number: 210-498-3
MDL Number: MFCD00004880
Linear Formula: HSCH₂CH(NHCOCH₃)CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHR1098-1G	1 g	$97.50 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to BP 907
	traceable to Ph. Eur. A0150000
	traceable to USP 1009005
API family	acetylcysteine
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChI key	PWKSKIMOESPYIA-BYPYZUCNSA-N
mp	106-108 °C (lit.)
Quality Level	300
SMILES string	CC(=O)N[C@@H](CS)C(O)=O
storage condition	protect from light
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Application:	N-Acetyl-L-cysteine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography-mass spectrometry (LC-MS) and spectrophotometric techniques.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAC0297in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine. It finds use in clinical applications as a mucolytic agent typically administered by inhalation.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Recommended products:	Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial .

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P264 - P280 - P305 + P351 + P338 - P337 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	106-108 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	41116107

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