Propyl gallate
SIAL/PHR1118 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: PG; 3,4,5-
CAS Number: 121-79-9
Empirical Formula (Hill Notation): C10H12O5
Molecular Weight: 212.20
EC Number: 204-498-2
MDL Number: MFCD00002196
Linear Formula: 3,4,5-(HO)3C6H2CO2CH2CH2CH3
Product Type: Chemical
agency | traceable to Ph. Eur. P3640000 |
traceable to USP 1576800 | |
application(s) | cleaning products cosmetics flavors and fragrances food and beverages personal care pharmaceutical (small molecule) |
CofA | current certificate can be downloaded |
format | neat |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C10H12O5/c1-2-3-15-10( |
InChI key | ZTHYODDOHIVTJV-UHFFFAOYSA |
mp | 146-149 °C (lit.) |
Quality Level | 300 ![]() |
SMILES string | CCCOC(=O)c1cc(O)c(O)c(O)c |
storage temp. | 2-30°C |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
Application: | Propyl gallate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fatty liquids by chromatography and spectrophotometry. |
Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
Application: | Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein. |
Biochem/physiol Actions: | An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. |
Biochem/physiol Actions: | An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA8981 in the slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propyl gallate is a synthetic phenolic antioxidant (SPA) utilized in food additives to inhibit or regulate the lipid oxidation. SPAs are cost-effective, largely available and highly efficient in comparison to their natural counterparts. |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Reconstitution: | Prepare a 0.1M solution in glycerol:PBS (9:1) |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H302 - H317 - H318 - H410 |
Precautionary statements | P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 22-43 |
Safety Statements | 24-37 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | 368.6 °F - closed cup |
Flash Point(C) | 187 °C - closed cup |
mp | 146-149 °C (lit.) |
Storage Temp. | 2-30°C |
UNSPSC | 41116107 |