2-Phenoxyethanol
SIAL/PHR1121 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Ethylene glycol monophenyl ether; PHE; PHE-G; PHE-S; PhG; Phenylglycol
CAS Number: 122-99-6
Empirical Formula (Hill Notation): C8H10O2
Molecular Weight: 138.16
EC Number: 204-589-7
MDL Number: MFCD00002857
Linear Formula: C6H5OCH2CH2OH
Product Type: Chemical
| agency | traceable to Ph. Eur. P0950000 |
| traceable to USP 1526200 | |
| application(s) | pharmaceutical (small molecule) |
| bp | 244-246 °C |
| CofA | current certificate can be downloaded |
| density | 1.107 g/mL at 20 °C (lit.) |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C8H10O2/c9-6-7-10-8-4- |
| InChI key | QCDWFXQBSFUVSP-UHFFFAOYSA |
| mp | 11-13 °C |
| Quality Level | 300  |
| SMILES string | OCCOc1ccccc1 |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | The pharmaceutical secondary standard can also be used as follows:• To determine phenoxyethanol and its major metabolite, phenoxyacetic acid by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma, urine, and 7 different tissue samples • Development of a reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method to quantify 2-phenoxyethanol from commercially available human vaccines • Screening of cosmetic products (CPs) for 17 widely used preservatives by high-performance liquid chromatography-photodiode • Thin layer chromatography (TLC)-densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in cream samples • Analysis of eight volatile and semi-volatile ingredients in a topical formulation by gas chromatography (GC) coupled with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC2814 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H319 |
| Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 258.8 °F - closed cup |
| Flash Point(C) | 126 °C - closed cup |
| bp | 244-246 °C |
| mp | 11-13 °C |
| Density | 1.107 g/mL at 20 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |