Phenytoin
SIAL/PHR1139 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 5,5-
CAS Number: 57-41-0
Empirical Formula (Hill Notation): C15H12N2O2
Molecular Weight: 252.27
EC Number: 200-328-6
MDL Number: MFCD00005264
Linear Formula: C15H12N2O2
Product Type: Chemical
| agency | traceable to Ph. Eur. P1290000 |
| traceable to USP 1535008 | |
| API family | phenytoin |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C15H12N2O2/c18-13-15(1 |
| InChI key | CXOFVDLJLONNDW-UHFFFAOYSA |
| mp | 293-295 °C (lit.) |
| Quality Level | 300  |
| SMILES string | O=C1NC(=O)C(N1)(c2ccccc2) |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Phenytoin may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by electrochemical, spectrophotometric, and chromatographic techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB7779 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Phenytoin is a well-known aromatic anticonvulsant which undergoes metabolism in the hepatic microsomal system. It finds its application as the most effective treatment available for seizure disorders. It belongs to the class of phenyl hydantoins compounds. It can hinder the unnecessary activity of the brain during seizures by bringing stability to the sodium channels, causing decreased electrical conductivity among brain cells. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Other Notes: | Values of analytes vary lot to lot. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H351 - H360FD |
| Precautionary statements | P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 45-61-22 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| mp | 293-295 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |