Acetaminophen Related Compound J
SIAL/PHR1149 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 4′-Chloroacetanilide; N-
CAS Number: 539-03-7
Empirical Formula (Hill Notation): C8H8ClNO
Molecular Weight: 169.61
EC Number: 208-707-8
MDL Number: MFCD00000612
Linear Formula: CH3CONHC6H4Cl
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0001945 |
| traceable to USP 1003100 | |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C8H8ClNO/c1-6(11)10-8- |
| InChI key | GGUOCFNAWIODMF-UHFFFAOYSA |
| mp | 176-178 °C (lit.) |
| Quality Level | 100  |
| 300 |
|
| SMILES string | CC(=O)Nc1ccc(Cl)cc1 |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | This pharmaceutical secondary standard can also be used as follows: • Separation and estimation of acetaminophen and its process impurities in commercial acetaminophen tablets using high-performance liquid chromatography (HPLC) • Development and validation of HPLC-based stability indicating method for the determination of acetaminophen, chlorpheniramine maleate, and their possible degradation products in an over-the-counter syrup formulation • Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methods • Impurity analysis of a combined suppository dosage form of paracetamol, codeine phosphate hemihydrate, and pitophenone hydrochloride using ion-pair reversed-phase liquid chromatography in combination with UV detection • Development of a thin-layer chromatography method combined with densitometry for the separation of acetaminophen and its related impurities from commercial dosage forms |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC0397 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol. |
| Other Notes: | Values of analytes vary lot to lot. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 176-178 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |