Amiodarone hydrochloride
SIAL/PHR1164 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: (2-
CAS Number: 19774-82-4
Empirical Formula (Hill Notation): C25H29I2NO3 · HCl
Molecular Weight: 681.77
EC Number: 243-293-2
MDL Number: MFCD00069204
Linear Formula: C25H29I2NO3 · HCl
Product Type: Chemical
| agency | traceable to BP 532 |
| traceable to Ph. Eur. A0575000 | |
| traceable to USP 1027302 | |
| API family | amiodarone |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C25H29I2NO3.ClH/c1-4-7 |
| InChI key | ITPDYQOUSLNIHG-UHFFFAOYSA |
| Quality Level | 300  |
| SMILES string | C(=O)(C=1C=2C(OC1CCCC)=CC |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Amiodarone hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Non-selective ion channel blocker |
| Biochem/physiol Actions: | Non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3555 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amiodarone hydrochloride is an antiarrhythmic drug used for the treatment of ventricular and supraventricular tachycardia. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Other Notes: | Values of analytes vary lot to lot. |
| Symbol |    GHS07,GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H312 + H332 - H315 - H319 - H361d - H373 - H410 |
| Precautionary statements | P201 - P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |