Tretinoin
SIAL/PHR1187 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Retinoic acid; ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid
CAS Number: 302-79-4
Empirical Formula (Hill Notation): C20H28O2
Molecular Weight: 300.44
EC Number: 206-129-0
MDL Number: MFCD00001551
Linear Formula: C20H28O2
Product Type: Chemical
| agency | traceable to Ph. Eur. T1850000 |
| traceable to USP 1674004 | |
| API family | tretinoin |
| application(s) | food and beverages |
| CofA | current certificate can be downloaded |
| form | solid |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C20H28O2/c1-15(8-6-9-1 |
| InChI key | SHGAZHPCJJPHSC-YCNIQYBTSA |
| mp | 180-181 °C (lit.) |
| Quality Level | 300  |
| SMILES string | CC1=C(C=CC(C)=CC=CC(C |
| storage temp. | -10 to -25°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Application: | Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques. |
| Biochem/physiol Actions: | all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 |
| Precautionary statements | P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 180-181 °C (lit.) |
| Storage Temp. | -10 to -25°C |
| UNSPSC | 41116107 |