Benzophenone
SIAL/PHR1204 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Diphenyl ketone; Diphenylmethanone; NSC 8077
CAS Number: 119-61-9
Empirical Formula (Hill Notation): C13H10O
Molecular Weight: 182.22
EC Number: 204-337-6
MDL Number: MFCD00003076
Linear Formula: (C6H5)2CO
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0000647 |
| API family | benzophenone |
| application(s) | cleaning products cosmetics flavors and fragrances food and beverages personal care pharmaceutical (small molecule) |
| bp | 305 °C (lit.) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C13H10O/c14-13(11-7-3- |
| InChI key | RWCCWEUUXYIKHB-UHFFFAOYSA |
| mp | 47-51 °C (lit.) |
| Quality Level | 300  |
| SMILES string | O=C(C1=CC=CC=C1)C2=CC=CC= |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor pressure | 1 mmHg ( 108 °C) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Benzophenone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic, spectrophotometric and polarographic techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3932 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Benzophenone is widely used in the manufacture of cosmetics and pharmaceuticals for its UV rays absorbing and fragrance retention abilities. Due to its ability to absorb ultraviolet radiations harmful in the form of UVA (320-400 nm) and UVB (290-320 nm), it is effective against skin disorders and skin cancer. It is used in the synthesis of antihistamines, hypnotics, and insecticides and is present as a potential impurity in diphenhydramine hydrochloride, phenytoin bulk powder, and phenytoin dosage forms. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H373 - H412 |
| Precautionary statements | P260 - P273 - P314 - P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 40-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 280.4 °F - closed cup |
| Flash Point(C) | 138 °C - closed cup |
| bp | 305 °C (lit.) |
| mp | 47-51 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |