Methyl salicylate
SIAL/PHR1214 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 2-Hydroxybenzoic acid methyl ester; Methyl 2-hydroxybenzoate; Oil of wintergreen; Wintergreen oil
CAS Number: 119-36-8
Empirical Formula (Hill Notation): C8H8O3
Molecular Weight: 152.15
EC Number: 204-317-7
MDL Number: MFCD00002214
Linear Formula: 2-(HO)C6H4CO2CH3
Product Type: Chemical
agency | traceable to USP 1537450 |
application(s) | pharmaceutical (small molecule) |
autoignition temp. | 847 °F |
bp | 222 °C (lit.) |
CofA | current certificate can be downloaded |
density | 1.174 g/mL at 25 °C (lit.) |
format | neat |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C8H8O3/c1-11-8(10)6-4- |
InChI key | OSWPMRLSEDHDFF-UHFFFAOYSA |
mp | −8-−7 °C (lit.) |
Quality Level | 300 ![]() |
refractive index | n |
SMILES string | COC(=O)c1ccccc1O |
storage temp. | 2-8°C |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable | |
vapor density | 5.26 (vs air) |
vapor pressure | 1 mmHg ( 54 °C) |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
Application: | Methyl salicylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and voltammetry techniques. |
Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3556 in the slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methyl salicylate is one of the common ingredients present in topical analgesics and rubifacients. It is prescribed for the management of minor muscle aches and pains. |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 1 |
Flash Point(F) | 204.8 °F - closed cup |
Flash Point(C) | 96 °C - closed cup |
bp | 222 °C (lit.) |
mp | −8-−7 °C (lit.) |
Density | 1.174 g/mL at 25 °C (lit.) |
Refractive Index | n |
Storage Temp. | 2-8°C |
UNSPSC | 41116107 |