Carvedilol

SIAL/PHR1265 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Carvedilol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; BM-14190

CAS Number: 72956-09-3
Empirical Formula (Hill Notation): C₂₄H₂₆N₂O₄
Molecular Weight: 406.47
MDL Number: MFCD00864692
Linear Formula: C₂₄H₂₆N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1265-1G	1 g	$115.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. Y0001427
	traceable to USP 1096622
API family	carvedilol
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
InChI key	OGHNVEJMJSYVRP-UHFFFAOYSA-N
Quality Level	300
SMILES string	OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
storage temp.	2-30°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application:	Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity.
Biochem/physiol Actions:	Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.
Disclaimer:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
General description:	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Carvedilol is a lipophilic β₁- and β₂-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.
Other Notes:	To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.

Symbol	GHS09
Hazard statements	H411
Precautionary statements	P273
Hazard Codes	N
Risk Statements	51/53
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-30°C
UNSPSC	41116107

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